Localization and Distribution of Voltage-Gated Na Channels
نویسنده
چکیده
There are nine recognized members of the voltage-gated Na+ channel family (VGSC; Nav1.1Nav1.9). Of these, Nav1.1, Nav1.2, Nav1.3 and Nav1.6 are highly (but not exclusively) expressed in the central nervous system (CNS), whereas Nav1.7, Nav1.8 and Nav1.9 demonstrate a more restricted expression pattern in autonomic and sensory neurons of the peripheral nervous system (PNS). Nav1.4 and Nav1.5 represent the predominant skeletal muscle and cardiac Na+ channels, respectively. The Nav1.6 subtype is also highly expressed in the peripheral nervous system where it is enriched at the nodes of Ranvier of myelinated axons and contributes to saltatory conduction4,18.
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تاریخ انتشار 2010